首页工具

登录

搜索结果

Search Results for " obesity factor "

Targets Recommended: EGFR HCV Protease Influenza Virus HER PDGFR

4

抑制剂 & 化合物

2

天然产物

13

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T2047	AG-1478 AG1478,NSC 693255,Tyrphostin AG-1478	EGFR; HCV Protease; Influenza Virus; HER; PDGFR	Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	AG-1478 (NSC-693255) 是一种选择性 EGFR 酪氨酸激酶抑制剂，IC50为 3 nM。它对 HCV 和脑心肌炎病毒有抗病毒作用。
T19710	Ciglitazone Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878	Apoptosis; p38 MAPK; PPAR	Apoptosis; DNA Damage/DNA Repair; MAPK; Metabolism
	Ciglitazone (ADD 3878) 是一种强效和选择性的PPARγ激动剂(EC50：3μM)和口服降糖药。Ciglitazone 抑制th17细胞的增殖和分化，降低胰岛素水平、血管内皮生长因子的产生和血压，诱导胃癌细胞的细胞周期停止。Ciglitazone 能诱导负鼠肾上皮细胞的凋亡，激活p38 MAPK 和凋亡诱导因子(AIF)的核转位。 Ciglitazone 在肥胖症和高血糖症的动物模型中表现出降血糖活性。
T75893	CRF(6-33)(human) TFA
	CRF(6-33)(human) TFA 是一种 CRF 结合蛋白配体 (CRF-BP) 抑制剂，与CRF-BP 竞争性结合，但不与突触后 CRF 受体结合。CRF(6-33)(human) TFA 具有抗肥胖作用。
T68302	KD3010 tosylate
	KD-3010 is a peroxisome proliferator-activated receptor delta agonist potentially for the treatment of diabetes and obesity. KD-3010 dramatically ameliorates liver injury induced by carbon tetrachloride (CCl(4)) injections. Deposition of extracellular matrix proteins was lower in the KD3010-treated group than in the vehicle- or GW501516-treated group. Interestingly, profibrogenic connective tissue growth factor was induced significantly by GW501516, but not by KD-3010, following CCl(4) treatmen...

化合物

Cat.No: T2047

Synonym: AG1478,NSC 693255,Tyrphostin AG-1478

Target: EGFR, HCV Protease, Influenza Virus, HER, PDGFR

Cat.No: T19710

Synonym: Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878

Target: Apoptosis, p38 MAPK, PPAR

CRF(6-33)(human) TFA

Cat.No: T75893

KD3010 tosylate

Cat.No: T68302

Cat. No.	Product Name	Target	Signaling Pathways
TN2019	Orobol 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮	BCL; Caspase; PI3K	Apoptosis; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) 是酪氨酸特异性蛋白激酶和磷脂酰肌醇转换的抑制剂。Orobol 抑制 PI3K，对 PI3K α/β/γ/K/δ 的 IC50 为 3.46-5.27 μM。 Orobol 具有抗皮肤老化和抗肥胖的作用。
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

Cat.No: TN2019

Synonym: 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮

Target: BCL, Caspase, PI3K

(E)-Guggulsterone

Cat.No: T36563

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00606	Leptin Protein, Carassius auratus, Recombinant (His) OB,Leptin,LEP,Obese Protein,OBS,Obesity Factor<...	Carassius auratus	P. pastoris (Yeast)
	Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. In mammals, leptin is mainly produced by the adipose tissue and encodes body fat reserves, acting as a short-term satiety signal. In fish, the presence of a leptin-like peptide was first evidenced by immuno-cross-reactivity, and its existence was certainly demonstrated after the finding by synteny ...
TMPK-00050	Leptin Protein, Mouse, Recombinant (hFc) LEP,Obesity factor,Leptin,LEPD,Obese prote...	Mouse	HEK293 Cells
	Leptin has key roles in the regulation of energy balance, body weight, metabolism, and endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenital leptin deficiency (CLD) due to mutations in the leptin gene.
TMPJ-00052	Leptin Protein, Mouse, Recombinant OB,Obesity Factor,OBS,LEP,Obese Protein,Le...	Mouse	E. coli
	Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin defici...
TMPK-01243	GDF-15 Protein, Rat, Recombinant (His) GDF-15,PDF,PTGF-beta,MIC-1,MIC1,GDF15,PTGFBPTGF-beta,NAG-1,P...	Rat	E. coli
	Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.68 kDa and the accession number is Q9Z0J6.
TMPK-00369	HGF Protein, Human, Recombinant (hFc) HGF,F-TCF,HGFB,SF,F-TCFB,肝细胞生长因子,DFNB39,Hepatopoietin-A,HPTA	Human	HEK293 Cells
	Hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity. HGF has a role in the metabolic flux of glucose in different insulin sensitive cell types; plays a key role in β-cell homeostasis; and is capable of modulating the inflammatory response.HGF plays a central role in these metabolic disorders,HGF levels could be employed as a biomarker for disease status/progression, and HGF/c-Met signaling pa...
TMPK-00569	GDF-15 Protein, Canine, Recombinant (His) GDF15,MIC1,MIC-1,PLAB,GDF-15,PDF,PTGFB,PTGF-beta,RG-1,Placen...	Canine	E. coli
	Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Canine, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.12 kDa and the accession number is A0A8C0TNP6.
TMPK-00196	GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated NAG-1,Placental TGF-beta,PTGFBPTGF-β,PDF,Placental TGF-β,PTG...	Human	E. coli
	Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 15.19 kDa and the accession nu...
TMPJ-01473	BMP-7 Protein, Human, Recombinant Eptotermin alfa,OP-1,OP1,Osteogenic protein 1,Bone morphogen...	Human	HEK293 Cells
	Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a...
TMPJ-00014	Resistin Protein, Human, Recombinant (His) Resistin,C/EBP-epsilon-regulated myeloid-specific secreted c...	Human	E. coli
	Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement wit...
TMPJ-00715	FGF-19 Protein, Human, Recombinant (His) FGF-19,Fibroblast growth factor 19,FGF19	Human	E. coli
	Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile ...
TMPJ-01459	FGF-21 Protein, Cynomolgus, Recombinant (His) Fibroblast Growth Factor 21,FGF-21,FGF21	Cynomolgus	HEK293 Cells
	Fibroblast Growth Factor 21 (FGF21) is a growth factor that belongs to the FGF family. FGF family proteins play a central role during prenatal development and postnatal growth and regeneration of mamy tissues, by promoting cellular proliferation and differentiation. FGF21 is a potent activator of glucose uptake on adipocytes, protects animal from diet-induced obesity when overexpression in transgenic mice, and lower blood glucose and triglyceride levels when therapeutically adiministered to diab...
TMPY-03419	SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST) SMAD family member 3	Human,Mouse,Rat	Baculovirus Insect Cells
	SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice,...
TMPY-06836	NR3C1 Protein, Human, Recombinant (His) GCCR,GRL,GR,nuclear receptor subfamily 3, group C, member 1 ...	Human	E. coli
	NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) is a Protein Coding gene. This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. NR3C1 is a transcriptional regulator of many drug-metabolizing enzymes and anti-inflammatory molecules. NR3C1 polymorphisms associate with obesi...

重组蛋白

Leptin Protein, Carassius auratus, Recombinant (His)

Cat.No: TMPJ-00606

Species: Carassius auratus

Expression System: P. pastoris (Yeast)

Leptin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00050

Species: Mouse

Expression System: HEK293 Cells

Leptin Protein, Mouse, Recombinant

Cat.No: TMPJ-00052

Species: Mouse

Expression System: E. coli

GDF-15 Protein, Rat, Recombinant (His)

Cat.No: TMPK-01243

Species: Rat

Expression System: E. coli

HGF Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00369

Species: Human

Expression System: HEK293 Cells

GDF-15 Protein, Canine, Recombinant (His)

Cat.No: TMPK-00569

Species: Canine

Expression System: E. coli

GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00196

Species: Human

Expression System: E. coli

BMP-7 Protein, Human, Recombinant

Cat.No: TMPJ-01473

Species: Human

Expression System: HEK293 Cells

Resistin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00014

Species: Human

Expression System: E. coli

FGF-19 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00715

Species: Human

Expression System: E. coli

FGF-21 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-01459

Species: Cynomolgus

Expression System: HEK293 Cells

SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)

Cat.No: TMPY-03419

Species: Human,Mouse,Rat

Expression System: Baculovirus Insect Cells

NR3C1 Protein, Human, Recombinant (His)

Cat.No: TMPY-06836

Species: Human

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼